Background: The management of acute and chronic pain for individuals living with sickle cell
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Methodological advancements, including propensity score methods, have resulted in
improved unbiased estimation of treatment effects from observational data. Traditionally, a …

purpose. Manufacturing. Distribution. Exportation and sale. The Controlled Substance Act
established five drug schedules and classified them to control their manufacture and …

Abstract The Veterans Health Administration (VHA) designed the Opioid Safety Initiative
(OSI) to help decrease opioid prescribing practices associated with adverse outcomes. Key …

Importance Prescription opioid misuse is a national crisis. Few interventions have improved
adherence to opioid-prescribing guidelines. Objective To determine whether a …

Background Practitioners and policy makers need evidence to facilitate the selection of
effective prevention interventions that can address the ongoing opioid overdose epidemic in …

Objectives: Review general guideleines for safe prescribing practices. Describe behaviors
that suggest drug diversion or drug-seeking and appropriate responses. Outline expected …

Opioid use and abuse for acute and chronic pain are a significant problem in the United
States and Tennesee.[1][2][3] The rate of overdose-related to the use of illicit opioids has …

Use of the prescription opioid methadone for treatment of pain, rather than for treatment of
opioid use disorder, has been identified as an important contributor to the rise in opioid …