Metalloproteinases and their inhibitors: potential for the development of new therapeutics
M Raeeszadeh-Sarmazdeh, LD Do, BG Hritz - Cells, 2020 - mdpi.com
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
The rebirth of matrix metalloproteinase inhibitors: moving beyond the dogma
GB Fields - Cells, 2019 - mdpi.com
The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …
Polymeric nanoparticles in gene therapy: New avenues of design and optimization for delivery applications
The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …
[HTML][HTML] Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …
development and progression. While many of the different MMPs expressed in breast cancer …
Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small …
AK Ludwig, K De Miroschedji… - Journal of …, 2018 - Taylor & Francis
Extracellular vesicles (EVs) provide a complex means of intercellular signalling between
cells at local and distant sites, both within and between different organs. According to their …
cells at local and distant sites, both within and between different organs. According to their …
Mmp-9 inhibition: a therapeutic strategy in ischemic stroke
M Chaturvedi, L Kaczmarek - Molecular neurobiology, 2014 - Springer
Ischemic stroke is a leading cause of disability worldwide. In cerebral ischemia there is an
enhanced expression of matrix metallo-proteinase-9 (MMP-9), which has been associated …
enhanced expression of matrix metallo-proteinase-9 (MMP-9), which has been associated …
Therapeutic potential of matrix metalloproteinase inhibition in breast cancer
ES Radisky… - Journal of cellular …, 2017 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …
components of the extracellular matrix as well as many other soluble and cell‐associated …
[HTML][HTML] Matrix metalloproteinases as breast cancer drivers and therapeutic targets
ES Radisky, DC Radisky - Frontiers in bioscience (Landmark …, 2015 - ncbi.nlm.nih.gov
Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …
Recent developments in protein and peptide parenteral delivery approaches
A Patel, K Cholkar, AK Mitra - Therapeutic delivery, 2014 - Taylor & Francis
Discovery of insulin in the early 1900s initiated the research and development to improve
the means of therapeutic protein delivery in patients. In the past decade, great emphasis has …
the means of therapeutic protein delivery in patients. In the past decade, great emphasis has …
Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins
MS Hamid Akash, K Rehman, S Chen - Polymer Reviews, 2015 - Taylor & Francis
In order to cure and treat health-related disorders, therapeutic substance must reach its
target site with a constant concentration over a long period of time. As oral administration is …
target site with a constant concentration over a long period of time. As oral administration is …