The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
PI Mackenzie, KW Bock, B Burchell… - Pharmacogenetics …, 2005 - journals.lww.com
Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases,
have been identified in the human, mouse and rat genomes and in other mammalian …
have been identified in the human, mouse and rat genomes and in other mammalian …
BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
Y Djoumbou-Feunang, J Fiamoncini… - Journal of …, 2019 - Springer
Background A number of computational tools for metabolism prediction have been
developed over the last 20 years to predict the structures of small molecules undergoing …
developed over the last 20 years to predict the structures of small molecules undergoing …
UDP-glucuronosyltransferases and clinical drug-drug interactions
TKL Kiang, MHH Ensom, TKH Chang - Pharmacology & therapeutics, 2005 - Elsevier
UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …
[图书][B] Swine in the laboratory: surgery, anesthesia, imaging, and experimental techniques
MM Swindle - 2007 - taylorfrancis.com
To diminish the learning curve associated with using swine as models, Swine in the
Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition …
Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition …
Xenobiotic metabolomics: major impact on the metabolome
Xenobiotics are encountered by humans on a daily basis and include drugs, environmental
pollutants, cosmetics, and even components of the diet. These chemicals undergo …
pollutants, cosmetics, and even components of the diet. These chemicals undergo …
The role of drug metabolizing enzymes in clearance
L Di - Expert opinion on drug metabolism & toxicology, 2014 - Taylor & Francis
Introduction: Metabolism is one of the most important clearance pathways representing the
major clearance route of 75% drugs. The four most common drug metabolizing enzymes …
major clearance route of 75% drugs. The four most common drug metabolizing enzymes …
Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT)
KM Knights, A Rowland… - British journal of clinical …, 2013 - Wiley Online Library
Although knowledge of human renal cytochrome P450 (CYP) and UDP‐
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …
Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and …
V Uchaipichat, PI Mackenzie, XH Guo… - Drug Metabolism and …, 2004 - ASPET
The glucuronidation kinetics of the prototypic substrates 4-methylumbelliferone (4MU) and 1-
naphthol (1NP) by human UDP-glucuronosyltransferases (UGT) 1A1, 1A3, 1A4, 1A6, 1A7 …
naphthol (1NP) by human UDP-glucuronosyltransferases (UGT) 1A1, 1A3, 1A4, 1A6, 1A7 …
The influence of plant secondary metabolites on the nutritional ecology of herbivorous terrestrial vertebrates
MD Dearing, WJ Foley, S McLean - Annu. Rev. Ecol. Evol. Syst., 2005 - annualreviews.org
▪ Abstract Plant secondary metabolites (PSMs) significantly impact the nutritional ecology of
terrestrial vertebrate herbivores. Herbivores have a wide range of mechanisms (herbivore …
terrestrial vertebrate herbivores. Herbivores have a wide range of mechanisms (herbivore …