Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which
is caused by more than 20 types of Candida sp., with C. albicans being the most common …

The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …

The evolution of resistance poses an ongoing threat to crop protection. Fungicide resistance
provides a selective advantage under fungicide selection, but resistance-conferring …

Pyroptosis is an inflammasome-mediated programmed cell death pathway triggered in
macrophages by a variety of stimuli, including intracellular bacterial pathogens. Activation of …

Clonal outbreaks of fluconazole-resistant (FLZR) Candida parapsilosis isolates have been
reported in several countries. Despite its being the second leading cause of candidemia, the …

The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …

Due to the high incidence of fungal infections worldwide, there is an increasing demand for
the development of novel therapeutic approaches. A wide range of natural products has …

Candida albicans represents one of the most common fungal pathogens. Due to its
increasing incidence and the poor efficacy of available antifungals, finding novel antifungal …

The yeast Candida albicans is a member of the microbiota in the gastrointestinal and
urogenital tracts of most healthy persons, but it can also cause symptomatic infections …

A critical risk to the continued success of antifungal chemotherapy is the acquisition of
resistance; a risk exacerbated by the few classes of effective antifungal drugs. Predictably …