Energy demand of neurons in brain that is covered by glucose supply from the blood is
ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative …

Although the brain has been considered an insulin-insensitive organ, recent reports on the
location of insulin and its receptors in the brain have introduced new ways of considering …

Alzheimer's disease (AD) and diabetes are currently considered among the top threats to
human health worldwide. Intriguingly, a connection between these diseases has been …

It is widely recognized that obesity and associated metabolic changes are considered a risk
factor to age-associated cognitive decline. Inflammation and increased oxidative stress in …

Historically, insulin is best known for its role in peripheral glucose homeostasis, and insulin
signaling in the brain has received less attention. Insulin-independent brain glucose uptake …

Abstract Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are
leading causes of disability worldwide. Indeed, both are costly and burdensome diseases at …

Arduous efforts have been made in the last three decades to elucidate the role of insulin in
the brain. A growing number of evidences show that insulin is involved in several …

Abstract Zinc-α2-glycoprotein (ZAG), encoded by the AZGP1 gene, is a major
histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been …

Previous studies suggest that insulin-sensitizing agents could play a significant role in the
treatment of major depression, particularly depression in patients with documented insulin …

OBJECTIVE Insulin released by the β-cell is thought to act locally to regulate glucagon
secretion. The possibility that insulin might also act centrally to modulate islet glucagon …