Current knowledge on exosome biogenesis, cargo-sorting mechanism and therapeutic implications

S Xie, Q Zhang, L Jiang - Membranes, 2022 - mdpi.com
Extracellular vesicles (EVs) are nanoscale membrane vesicles released by donor cells that
can be taken up by recipient cells. The study of EVs has the potential to identify unknown …

Cell-derived nanovesicle-mediated drug delivery to the brain: principles and strategies for vesicle engineering

Y Liang, Z Iqbal, J Lu, J Wang, H Zhang, X Chen… - Molecular Therapy, 2023 - cell.com
Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

Exosomal miRNAs in tumor microenvironment

S Tan, L Xia, P Yi, Y Han, L Tang, Q Pan, Y Tian… - Journal of Experimental …, 2020 - Springer
Tumor microenvironment (TME) is the internal environment in which tumor cells survive,
consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non …

Cell entry and release of quasi-enveloped human hepatitis viruses

A Das, EE Rivera-Serrano, X Yin, CM Walker… - Nature Reviews …, 2023 - nature.com
Infectious hepatitis type A and type E are caused by phylogenetically distinct single-
stranded, positive-sense RNA viruses that were once considered to be non-enveloped …

Mechanism of cargo sorting into small extracellular vesicles

Y Chen, Y Zhao, Y Yin, X Jia, L Mao - Bioengineered, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are special membranous structures released by almost every
cell type that carry and protect some biomolecules from being degraded. They transport …

A new infectious unit: extracellular vesicles carrying virus populations

A Kerviel, M Zhang… - Annual Review of Cell and …, 2021 - annualreviews.org
Viral egress and transmission have long been described to take place through single free
virus particles. However, viruses can also shed into the environment and transmit as …

Exosome: a new player in translational nanomedicine

H Aheget, M Tristán-Manzano, L Mazini… - Journal of Clinical …, 2020 - mdpi.com
Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo
and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma …

Role of extracellular vesicles in liver diseases and their therapeutic potential

E Kostallari, S Valainathan, L Biquard, VH Shah… - Advanced drug delivery …, 2021 - Elsevier
More than eight hundred million people worldwide have chronic liver disease, with two
million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards …

[HTML][HTML] Multiplexed strategies toward clinical translation of extracellular vesicles

J Song, B Song, L Yuan, G Yang - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally
secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability …

Biomimetic exosomes: a new generation of drug delivery system

X Wang, X Zhao, Y Zhong, J Shen… - Frontiers in bioengineering …, 2022 - frontiersin.org
Most of the naked drugs, including small molecules, inorganic agents, and
biomacromolecule agents, cannot be used directly for disease treatment because of their …