Abstract P-glycoprotein (ABCB1), multidrug resistance protein-1 (ABCC1) and breast cancer
resistance protein (ABCG2) belong to the ATP-binding cassette (ABC) superfamily of …

Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug
resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied …

Malignant tumor endangers seriously the health of all mankind. Multidrug resistance (MDR)
is one of the main causes of clinical tumor chemotherapy failure. Curcumin (CUR) has not …

Abstract Development of multiple drug resistance (MDR) to chemotherapy is the major
reason for the failure of gastric cancer (GC) treatment. P-glycoprotein (P-gp), which is …

Abstract P-glycoprotein (P-gp), a membrane transport protein overexpressed in certain drug-
resistant cancer cells, has been the target of numerous drug discovery projects aimed at …

Objective (s): Multidrug resistance (MDR) is a major obstacle in the successful
chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP …

Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with
resistances in cancer chemotherapy. Intensive efforts to identify P-gp inhibitors for use in …

The transcription factor twist family bHLH transcription factor 1 (TWIST), which is a member
of the basic helix-loop-helix class of proteins, is known to induce epithelial-mesenchymal …

Multidrug resistance (MDR) to chemotherapeutic drugs remains one of the major
impediments to the treatment of cancer. Discovery and development of drugs that can …

Cisplatin (CDDP), as a broad-spectrum anticancer drug, is able to bind to DNA and inhibit
cell division. Despite the widespread use of cisplatin since its discovery, cisplatin resistance …