A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease
SH Waddell, Y Yao, P Olaizola, A Walker… - Science translational …, 2023 - science.org
The formation of multiple cysts in the liver occurs in a number of isolated monogenic
diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary …
diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary …
[HTML][HTML] Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells
Current studies are focusing on the anti-cancerous properties of natural bioactive
compounds, primarily those included in the human diet. These compounds have the …
compounds, primarily those included in the human diet. These compounds have the …
[HTML][HTML] JNJ-64619178 radiosensitizes and suppresses fractionated ionizing radiation-induced neuroendocrine differentiation (NED) in prostate cancer
Background Radiation therapy (RT) is a standard treatment regimen for locally advanced
prostate cancer; however, its failure results in tumor recurrence, metastasis, and cancer …
prostate cancer; however, its failure results in tumor recurrence, metastasis, and cancer …
Differential regulation of fibronectin expression and fibrillogenesis by autocrine TGF-β1 signaling in malignant and benign mammary epithelial cells
MM Sofroniou, CA Lemmon - The International Journal of Biochemistry & …, 2023 - Elsevier
Remodeling of the extracellular matrix (ECM) is a key hallmark of cancer progression. A
critical component of ECM remodeling is the assembly of the glycoprotein fibronectin (FN) …
critical component of ECM remodeling is the assembly of the glycoprotein fibronectin (FN) …
Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease
SH Waddell, Y Yao, P Olaizola, EJ Jarman… - bioRxiv, 2022 - biorxiv.org
Pathological liver cysts are an important comorbidity in multiple diseases and syndromes (,)
driven by dysfunction of the primary cilium (PC), a complex sensory organelle that protrudes …
driven by dysfunction of the primary cilium (PC), a complex sensory organelle that protrudes …