Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …

The tumor suppressor protein p53 is a redox-active transcription factor that organizes and
directs cellular responses in the face of a variety of stresses that lead to genomic instability …

Myc expression is deregulated in a wide range of human cancers and is often associated
with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that …

Doxorubicin (DOX) is a common anticancer drug. The mechanisms of DOX induced
apoptosis and the involvement of reactive oxygen species (ROS) in apoptotic signaling were …

Reactive oxygen species (ROS) are natural products inevitably generated along cellular
metabolism. Due to their highly reactive nature, which can damage DNA, proteins and lipids …

Melanoma cells can undergo self‐destruction via programmed cell death, ie apoptosis. In
these tumours, the molecular components of apoptosis include positive (apoptotic) and …

Aside from the well-established roles of c-Myc in the regulation of cell cycle, differentiation,
and apoptosis, a recent picture is beginning to emerge linking c-Myc to the regulation of …

Cells apoptosis induced by intense heat stress is the prominent feature of heat-related
illness. However, little is known about the biological effects of heat stress on cells apoptosis …

Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study,
the mechanism of anticancer effect of AA on skin cancer was investigated. AA decreased …

The purpose of this study was to investigate the molecular and therapeutic effects of siRNA-
mediated c-MYC silencing in cisplatin-resistant ovarian cancer. Statistical analysis of …