It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Oxidative stress was reported to be involved not only in cardiovascular diseases, but also in
hypertension. Epidemiologic studies indicated that tea consumption slightly reduces blood …

Evidence indicates that both the Rho/Rho kinase signaling pathway and reactive oxygen
species (ROS) such as superoxide and H2O2 are involved in the pathogenesis of …

Numerous studies have demonstrated the ability of a variety of vascular cells, including
endothelial cells, smooth muscle cells, and fibroblasts, to produce reactive oxygen species …

Hypertension affects nearly 20% of the population in Western countries and strongly
increases the risk for cardiovascular diseases. In the pathogenesis of hypertension, the …

Reactive oxygen species (ROS) are continuously generated in vascular tissues by various
oxidoreductase enzymes. They contribute to normal cell signaling, and modulate vascular …

Publisher Summary This chapter discusses the local control of microvascular perfusion,
which has been described as “the maintenance of appropriate tissue blood flow despite …

Aims In type 2 diabetes, antioxidant depletion contributes to increased oxidative stress in the
microvasculature. The current study was designed to assess how oxidative stress …

Hydrogen peroxide (H2O2) caused a transient contraction in endothelium‐intact (E+) and‐
denuded (E−) mesenteric arteries (MA) from 8–10‐month‐old spontaneously hypertensive …