The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

KE Wang, W Chen, Z Zhang, Y Deng, JQ Lian… - Signal transduction and …, 2020 - nature.com
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no
specific and effective drugs for treating this disease have been reported until today …

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

L Perico, A Benigni, F Casiraghi, LFP Ng… - Nature Reviews …, 2021 - nature.com
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …

The COVID-19 pandemic: a global health crisis

CA Pollard, MP Morran… - Physiological …, 2020 - journals.physiology.org
The novel coronavirus SARS-CoV-2 was identified as the causative agent for a series of
atypical respiratory diseases in the Hubei Province of Wuhan, China in December of 2019 …

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

RL Chua, S Lukassen, S Trump, BP Hennig… - Nature …, 2020 - nature.com
To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …

Chest CT in COVID-19: what the radiologist needs to know

TC Kwee, RM Kwee - Radiographics, 2020 - pubs.rsna.org
Chest CT has a potential role in the diagnosis, detection of complications, and
prognostication of coronavirus disease 2019 (COVID-19). Implementation of appropriate …

COVID-19: from an acute to chronic disease? Potential long-term health consequences

V Higgins, D Sohaei, EP Diamandis… - Critical reviews in …, 2021 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Despite pulmonary impairments being the most …

The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

Organ-specific manifestations of COVID-19 infection

M Gavriatopoulou, E Korompoki, D Fotiou… - Clinical and …, 2020 - Springer
Although COVID-19 presents primarily as a lower respiratory tract infection transmitted via
air droplets, increasing data suggest multiorgan involvement in patients that are infected …