Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - ASPET
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
The biology of ergothioneine, an antioxidant nutraceutical
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …
The SLC22 family with transporters of organic cations, anions and zwitterions
H Koepsell - Molecular aspects of medicine, 2013 - Elsevier
The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
The ergothioneine transporter (ETT): substrates and locations, an inventory
D Gründemann, L Hartmann, S Flögel - FEBS letters, 2022 - Wiley Online Library
In all vertebrates including mammals, the ergothioneine transporter ETT (obsolete name
OCTN1; human gene symbol SLC22A4) is a powerful and highly specific transporter for the …
OCTN1; human gene symbol SLC22A4) is a powerful and highly specific transporter for the …
Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?
Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high
concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may …
concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may …
Influences of organic cation transporter polymorphisms on the population pharmacokinetics of metformin in healthy subjects
This study investigated the effects of genetic polymorphisms in organic cation transporter
(OCT) genes, such as OCT1-3, OCTN1, MATE1, and MATE2-K, on metformin …
(OCT) genes, such as OCT1-3, OCTN1, MATE1, and MATE2-K, on metformin …
Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition
Drug pharmacokinetics is influenced by the function of metabolising enzymes and
influx/efflux transporters. Genetic variability of these genes is known to impact on clinical …
influx/efflux transporters. Genetic variability of these genes is known to impact on clinical …
Ergothioneine and central nervous system diseases
N Nakamichi, S Tsuzuku, F Shibagaki - Neurochemical Research, 2022 - Springer
Ergothioneine (ERGO) is a thiol contained in the food that exhibits an excellent antioxidant
effect similar to that of glutathione. Although mammals lack a biosynthetic pathway for …
effect similar to that of glutathione. Although mammals lack a biosynthetic pathway for …
Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental transporter proteins
ANA Daud, JEH Bergman, MK Bakker, H Wang… - …, 2014 - Taylor & Francis
One of the ongoing issues in perinatal medicine is the risk of birth defects associated with
maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the …
maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the …
Advances in drug metabolism and pharmacogenetics research in Australia
Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as
biotransformation products) of a myriad of structurally diverse drugs and other chemicals …
biotransformation products) of a myriad of structurally diverse drugs and other chemicals …