Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder,
characterized mainly by a loss of motor neurons (MNs) in the CNS. Over the past decades …

Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

Non-cell-autonomous mechanisms contribute to neurodegenerative diseases such as
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), in which astrocytes …

We and others have shown that transition and maintenance of biological states is controlled
by master regulator proteins, which can be inferred by interrogating tissue-specific …

Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal
recovery, but the mechanisms that determine these different responses are poorly …

Neuronal maturation requires dramatic morphological and functional changes, but the
molecular mechanisms governing this process are not well understood. Here, we studied …

Developing therapies for neurodegenerative diseases will require new scientific approaches
that take into account the detrimental effects of altered protein and RNA homeostasis on …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

Local control of gene expression provides critical mechanisms for regulating development,
maintenance and plasticity in the nervous system. Among the strategies known to govern …

The RNA-binding protein TDP-43 is heavily implicated in neurodegenerative disease.
Numerous patient mutations in TARDBP, the gene encoding TDP-43, combined with data …