Pathology and pathogenesis of Chagas heart disease

KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

Pathogenesis of chronic Chagas heart disease

JA Marin-Neto, E Cunha-Neto, BC Maciel, MV Simões - Circulation, 2007 - Am Heart Assoc
Background—Chagas disease remains a significant public health issue and a major cause
of morbidity and mortality in Latin America. Despite nearly 1 century of research, the …

Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment

EA Bocchi, RB Bestetti, MI Scanavacca… - Journal of the American …, 2017 - jacc.org
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a
worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T …

The role of infections in autoimmune disease

AM Ercolini, SD Miller - Clinical & Experimental Immunology, 2009 - academic.oup.com
Autoimmunity occurs when the immune system recognizes and attacks host tissue. In
addition to genetic factors, environmental triggers (in particular viruses, bacteria and other …

Chagas disease cardiomyopathy: immunopathology and genetics

E Cunha-Neto, C Chevillard - Mediators of inflammation, 2014 - Wiley Online Library
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America
and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop …

Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease

FS Machado, WO Dutra, L Esper, KJ Gollob… - Seminars in …, 2012 - Springer
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

[HTML][HTML] Evolution and pathology in Chagas disease: a review

ARL Teixeira, RJ Nascimento… - Memórias do Instituto …, 2006 - SciELO Brasil
Trypanosoma cruzi acute infections often go unperceived, but one third of chronically
infected individuals die of Chagas disease, showing diverse manifestations affecting the …

MicroRNAs: biological regulators in pathogen–host interactions

SM Acuna, LM Floeter-Winter, SM Muxel - Cells, 2020 - mdpi.com
An inflammatory response is essential for combating invading pathogens. Several effector
components, as well as immune cell populations, are involved in mounting an immune …

SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease–2023

JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
SciELO - Brazil - Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …

Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy

C Chevillard, JPS Nunes, AF Frade… - Frontiers in …, 2018 - frontiersin.org
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …