Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …
remarkable heterogeneity in their morphology and function. Besides their physical and …
[HTML][HTML] The making of the Drosophila mushroom body
S Lin - Frontiers in Physiology, 2023 - frontiersin.org
The mushroom body (MB) is a computational center in the Drosophila brain. The intricate
neural circuits of the mushroom body enable it to store associative memories and process …
neural circuits of the mushroom body enable it to store associative memories and process …
Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin
J Ma, LQ Zhang, ZX He, XX He, YJ Wang, YL Jian… - PLoS …, 2019 - journals.plos.org
Dendritic spine development is crucial for the establishment of excitatory synaptic
connectivity and functional neural circuits. Alterations in spine morphology and density have …
connectivity and functional neural circuits. Alterations in spine morphology and density have …
Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice
J Ma, K Li, X Sun, JN Liang, XQ An, M Tian, J Li… - Cerebral …, 2023 - academic.oup.com
Autism is often comorbid with other psychiatric disorders. We have previously shown that
Dip2a knockout (KO) induces autism-like behaviors in mice. However, the role of Dip2a in …
Dip2a knockout (KO) induces autism-like behaviors in mice. However, the role of Dip2a in …
Vaccines to prevent coccidioidomycosis: a gene-deletion mutant of Coccidioides posadasii as a viable candidate for human trials
Coccidioidomycosis is an endemic fungal infection that is reported in up to 20,000 persons
per year and has an economic impact close to $1.5 billion. Natural infection virtually always …
per year and has an economic impact close to $1.5 billion. Natural infection virtually always …
[HTML][HTML] DIP2A is involved in SOD-mediated antioxidative reactions in murine brain
LL Bai, LQ Zhang, J Ma, J Li, M Tian, RJ Cao… - Free Radical Biology …, 2021 - Elsevier
Autism spectrum disorders (ASDs) are highly associated with oxidative stress. We have
recently shown that Disconnected-interacting protein homolog 2 A (DIP2A) functions in ASD …
recently shown that Disconnected-interacting protein homolog 2 A (DIP2A) functions in ASD …
DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes
Chain-length-specific subsets of diacylglycerol (DAG) lipids are proposed to regulate
differential physiological responses ranging from signal transduction to modulation of the …
differential physiological responses ranging from signal transduction to modulation of the …
Targeted disruption of mouse Dip2B leads to abnormal lung development and prenatal lethality
Molecular and anatomical functions of mammalian Dip2 family members (Dip2A, Dip2B and
Dip2C) during organogenesis are largely unknown. Here, we explored the indispensable …
Dip2C) during organogenesis are largely unknown. Here, we explored the indispensable …
A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation
Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids
in mycobacteria and other pharmaceutically or ecologically important polyketides and …
in mycobacteria and other pharmaceutically or ecologically important polyketides and …
DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons
N Noblett, Z Wu, ZH Ding, S Park, T Roenspies… - Journal of Cell …, 2019 - rupress.org
Neuronal morphology and circuitry established during early development must often be
maintained over the entirety of animal lifespans. Compared with neuronal development, the …
maintained over the entirety of animal lifespans. Compared with neuronal development, the …