We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical
'periodic selection'model of clonal evolution assumed that beneficial mutations are very rare …

To learn about the past from a sample of genomic sequences, one needs to understand how
evolutionary processes shape genetic diversity. Most population genetics inferences are …

The dynamics of adaptation determine which mutations fix in a population, and hence how
reproducible evolution will be. This is central to understanding the spectra of mutations …

Epistatic interactions between mutations can make evolutionary trajectories contingent on
the chance occurrence of initial mutations. We used experimental evolution in …

The experimental evolution of laboratory populations of microbes provides an opportunity to
observe the evolutionary dynamics of adaptation in real time. Until very recently, however …

The fate of a newly arising beneficial mutation depends on many factors, such as the
population size and the availability and fitness effects of other mutations that accumulate in …

Recent advances in sequencing technologies have made available an ever-increasing
amount of ancient genomic data. In particular, it is now possible to target specific single …

Clonal interference, the competition between lineages arising from different beneficial
mutations in an asexually reproducing population, is an important factor determining the …

Bacteriophages (phages) are the viruses of bacteria and the study of phage biology can be
differentiated, roughly, into molecular, environmental, evolutionary, ecological, and applied …

We develop a new method for estimating effective population sizes, N e, and selection
coefficients, s, from time-series data of allele frequencies sampled from a single diallelic …