RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
Interplay of transcription factors in T‐cell differentiation and function: the role of Runx
WF Wong, K Kohu, T Chiba, T Sato, M Satake - Immunology, 2011 - Wiley Online Library
Over the past years, increasing numbers of distinct subsets have been discovered and
identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are …
identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are …
DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter
Despite the fact that 45% of all human gene promoters do not contain CpG islands, the role
of DNA methylation in control of non-CpG island promoters is controversial and its relevance …
of DNA methylation in control of non-CpG island promoters is controversial and its relevance …
Identification of sequence variants influencing immunoglobulin levels
S Jonsson, G Sveinbjornsson… - Nature …, 2017 - nature.com
Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a
genome-wide association study of 19,219 individuals, we found 38 new variants and …
genome-wide association study of 19,219 individuals, we found 38 new variants and …
Runx3 and Cell Fate Decisions in Pancreas Cancer
MC Whittle, SR Hingorani - RUNX Proteins in Development and Cancer, 2017 - Springer
The RUNX family transcription factors are critical regulators of development and frequently
dysregulated in cancer. RUNX3, the least well characterized of the three family members …
dysregulated in cancer. RUNX3, the least well characterized of the three family members …
Coreceptor gene imprinting governs thymocyte lineage fate
S Adoro, T McCaughtry, B Erman, A Alag… - The EMBO …, 2012 - embopress.org
Immature thymocytes are bipotential cells that are signalled during positive selection to
become either helper‐or cytotoxic‐lineage T cells. By tracking expression of lineage …
become either helper‐or cytotoxic‐lineage T cells. By tracking expression of lineage …
Increased genetic susceptibility to intestinal‐type gastric cancer is associated with increased activity of the RUNX3 distal promoter
BACKGROUND: The runt‐related transcription factor RUNX3 plays essential roles in various
types of tumors, including gastric cancer. Epigenetic changes in the methylation of the …
types of tumors, including gastric cancer. Epigenetic changes in the methylation of the …
Over‐expression of Runx1 transcription factor impairs the development of thymocytes from the double‐negative to double‐positive stages
WF Wong, M Nakazato, T Watanabe, K Kohu… - …, 2010 - Wiley Online Library
Runx1 transcription factor is highly expressed at a CD4/CD8‐double‐negative (DN) stage of
thymocyte development but is down‐regulated when cells proceed to the double‐positive …
thymocyte development but is down‐regulated when cells proceed to the double‐positive …
[HTML][HTML] Inactivation of RUNX3/p46 promotes cutaneous T-cell lymphoma
A Haider, A Steininger, R Ullmann, M Hummel… - Journal of Investigative …, 2016 - Elsevier
The key role of RUNX3 in physiological T-cell differentiation has been extensively
documented. However, information on its relevance for the development of human T-cell …
documented. However, information on its relevance for the development of human T-cell …
Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression
The transcription factor interferon regulatory factor 4 (IRF4) was originally found to be
preferentially expressed in lymphoid cells and to be required for the function, differentiation …
preferentially expressed in lymphoid cells and to be required for the function, differentiation …