Serpins are a superfamily of proteins characterized by their common function as serine
protease inhibitors. So far, 36 serpins from nine clades have been identified. These proteins …

To date, no curative therapy is available for the treatment of most chronic inflammatory
diseases such as atopic dermatitis, rheumatoid arthritis, or autoimmune disorders. Current …

Immunotoxins (ITs) are attractive anticancer modalities aimed at cancer-specific delivery of
highly potent cytotoxic protein toxins. An IT consists of a targeting domain (an antibody …

Understanding the molecular mechanisms of cancer biology introduces targeted therapy as
a complementary method along with other conventional therapies. Recombinant …

Proteases are often overexpressed in tumor cells and/or the stromal compartment and can
thus be exploited in tumor therapy to activate cytotoxic prodrugs as, for example, in cytolytic …

Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour
cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on …

Triple-negative breast cancer (TNBC) is associated with poor prognosis and high
prevalence among young premenopausal women. Unlike in other breast cancer subtypes …

Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the
damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or …

Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for
the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects …

Conventional cancer treatments lack specificity and often cause severe side effects.
Targeted therapeutic approaches are therefore preferred, including the use of immunotoxins …