The biological activity and structural diversity of natural products are unsurpassed by any
available synthetic screening libraries. As such, these privileged scaffolds serve as …

Antibody-drug conjugates (ADCs) represent a promising cancer therapy modality which
specifically delivers highly toxic payloads to cancer cells through antigen-specific …

The methodological developments in gold (I)-and gold (III)-catalyzed glycosylation reactions
are fully surveyed, which exploit the special alkynophilicity or the Lewis acidity of the gold …

The Hauser-Kraus annulation is one of the most powerful methods to construct polycyclic
hydroquinone from 3-cyano phthalides and Michael acceptors. Although these methods …

Conspectus The emergence and evolution of antibody–drug conjugates (ADCs) as targeted
cancer therapies in recent years is a living example of the “magic bullet” concept of Paul …

Mangrove actinomycetia are considered one of the promising sources for discovering novel
biologically active compounds. Traditional bioactivity-and/or taxonomy-based methods are …

Shishijimicin A is a scarce marine natural product with highly potent cytotoxicities, making it
a potential payload or a lead compound for designed antibody–drug conjugates. Herein, we …

Chirality is one of the most important attributes for its presence in a vast majority of bioactive
natural products and pharmaceuticals. Asymmetric organocatalysis methods have emerged …

Trioxacarcin (TXN) A was reported to be an anticancer agent through alkylation of dsDNA. G-
quadruplex DNA (G4-DNA) is frequently formed in the promoter regions of oncogenes and …

An aza analogue of the Rubottom oxidation is reported. This facile transformation takes
place at ambient temperature and directly converts silyl enol ethers to the corresponding …