In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic
lateral sclerosis has been intensively studied. However, the origin of these disorders …

Background Gray matter (GM) pathology is closely associated with physical and cognitive
impairment in persons with multiple sclerosis (PwMS). Similarly, serum neurofilament light …

Traumatic brain injury (TBI) consists of acute and long-term pathophysiological sequelae
that ultimately lead to cognitive and motor function deficits, with age being a critical risk …

Plasma neurofilament light (NfL) is a marker for neurodegenerative diseases. Few studies
have examined the association of NfL with middle-aged changes in cognitive performance …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) leading to demyelination and neurodegeneration. Life expectancy and age of onset …

Aging is associated with brain iron accumulation, which has been linked to cognitive
decline. However, how brain iron affects the structure and function of cognitive brain …

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease involving
immune-mediated damage. Iron deposition in deep gray matter (DGM) structures like the …

Magnetic resonance imaging has been crucial in the development of anti-inflammatory
disease-modifying treatments. The current landscape of multiple sclerosis clinical trials is …