Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Obesity‐related glomerulopathy (ORG) is a silent comorbidity which is increasing in
incidence as the obesity epidemic escalates. ORG is associated with serious health …

Purpose The potential of renal MRI biomarkers has been increasingly recognised, but
clinical translation requires more standardisation. The PARENCHIMA consensus project …

Free fatty acids (FFA) and other lipids have important normal physiologic functions, serving
as a source for energy, for cell wall components, for intra-and extracellular signaling, and …

Diabetic lipo-toxicity is a fundamental pathophysiologic mechanism in DM and is now
increasingly recognized a key determinant of DKD. Targeting lipid metabolic disorders is an …

Purpose We hypothesize that MRI-based renal compartment volumes, particularly renal
sinus fat as locally and potentially independently acting perivascular fat tissue, increase with …

Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery
disease, and valvular or congenital heart disease, is now recognized as a distinct …

Kidney diseases can be caused by a wide range of genetic, hemodynamic, toxic, infectious,
and autoimmune factors. The diagnosis of kidney disease usually involves the biochemical …

Objective Ectopic lipid accumulation in the kidney (fatty kidney) is a potential driver of
diabetic kidney disease, and tight glycemic control can reduce risk of diabetic nephropathy …

Purpose The purpose of this study was to evaluate different renal proton density fat fraction
(PDFF) analysis approaches. Additionally, we assessed renal fat in obese individuals and …