Amorphous pharmaceutical solids: preparation, characterization and stabilization

L Yu - Advanced drug delivery reviews, 2001 - Elsevier
The importance of amorphous pharmaceutical solids lies in their useful properties, common
occurrence, and physicochemical instability relative to corresponding crystals. Some …

Methods of amorphization and investigation of the amorphous state

T Einfalt, O Planinšek, K Hrovat - Acta pharmaceutica, 2013 - hrcak.srce.hr
Sažetak The amorphous form of pharmaceutical materials represents the most energetic
solid state of a material. It provides advantages in terms of dissolution rate and …

Characterization of amorphous solid dispersions and identification of low levels of crystallinity by transmission electron microscopy

M S'ari, H Blade, S Cosgrove… - Molecular …, 2021 - ACS Publications
Amorphous solid dispersions (ASDs) are used to increase the solubility of oral medicines by
kinetically stabilizing the more soluble amorphous phase of an active pharmaceutical …

Analysis of nanocrystal development in Al-Y-Fe and Al-Sm glasses

JC Foley, DR Allen, JH Perepezko - Scripta Materialia, 1996 - Elsevier
A high nucleation density is clearly an important prerequisite for the development of
nanocrystal dispersions during primary crystallization of metallic glass. A microstructure of …

Recent progress on modified gum katira polysaccharides and their various potential applications

M Singh, CJ Raorane, Alka, D Shastri, V Raj, SC Kim… - Polymers, 2022 - mdpi.com
Gum katira polysaccharide is biocompatible and non-toxic, and has antioxidant, anti-
microbial, and immunomodulatory properties. It is a natural polysaccharide and exudate …

Liquid-like relaxation in hyperquenched water at≤ 140 K

I Kohl, L Bachmann, A Hallbrucker, E Mayer… - Physical Chemistry …, 2005 - pubs.rsc.org
Micrometre-sized water droplets were hyperquenched on a solid substrate held at selected
temperatures between 150 and 77 K. These samples were characterized by differential …

Crystallization kinetics and glass-forming ability of rapidly crystallizing drugs studied by Fast Scanning Calorimetry

SE Lapuk, TA Mukhametzyanov, C Schick… - International Journal of …, 2021 - Elsevier
The use of the amorphous forms of drugs is a modern approach for the enhancement of
bioavailability. At the same time, the high cooling rate needed to obtain the metastable …

Glass formation and primary nanocrystallization in Al-base metallic glasses

RI Wu, G Wilde, JH Perepezko - Materials Science and Engineering: A, 2001 - Elsevier
Aluminum-rich metallic glasses containing transition metals and rare earth elements have
been found to yield finely mixed microstructures of Al nanocrystals embedded in an …

Kinetic stability of amorphous solid dispersions with high content of the drug: A fast scanning calorimetry investigation

SE Lapuk, LS Zubaidullina, MA Ziganshin… - International Journal of …, 2019 - Elsevier
Formation of amorphous solid dispersions is an effective way to enhance the bioavailability
of drugs. One of the main disadvantages of such systems is their low storage stability …

Finding the needle in the haystack: characterization of trace crystallinity in a commercial formulation of paclitaxel protein-bound particles by Raman spectroscopy …

PD Schmitt, NS Trasi, LS Taylor… - Molecular …, 2015 - ACS Publications
Second harmonic generation (SHG) microscopy was used to rapidly identify regions of
interest for localized confocal Raman spectroscopy measurements in order to quantify …