Amorphous pharmaceutical solids: preparation, characterization and stabilization
L Yu - Advanced drug delivery reviews, 2001 - Elsevier
The importance of amorphous pharmaceutical solids lies in their useful properties, common
occurrence, and physicochemical instability relative to corresponding crystals. Some …
occurrence, and physicochemical instability relative to corresponding crystals. Some …
Methods of amorphization and investigation of the amorphous state
T Einfalt, O Planinšek, K Hrovat - Acta pharmaceutica, 2013 - hrcak.srce.hr
Sažetak The amorphous form of pharmaceutical materials represents the most energetic
solid state of a material. It provides advantages in terms of dissolution rate and …
solid state of a material. It provides advantages in terms of dissolution rate and …
Characterization of amorphous solid dispersions and identification of low levels of crystallinity by transmission electron microscopy
M S'ari, H Blade, S Cosgrove… - Molecular …, 2021 - ACS Publications
Amorphous solid dispersions (ASDs) are used to increase the solubility of oral medicines by
kinetically stabilizing the more soluble amorphous phase of an active pharmaceutical …
kinetically stabilizing the more soluble amorphous phase of an active pharmaceutical …
Analysis of nanocrystal development in Al-Y-Fe and Al-Sm glasses
JC Foley, DR Allen, JH Perepezko - Scripta Materialia, 1996 - Elsevier
A high nucleation density is clearly an important prerequisite for the development of
nanocrystal dispersions during primary crystallization of metallic glass. A microstructure of …
nanocrystal dispersions during primary crystallization of metallic glass. A microstructure of …
Recent progress on modified gum katira polysaccharides and their various potential applications
M Singh, CJ Raorane, Alka, D Shastri, V Raj, SC Kim… - Polymers, 2022 - mdpi.com
Gum katira polysaccharide is biocompatible and non-toxic, and has antioxidant, anti-
microbial, and immunomodulatory properties. It is a natural polysaccharide and exudate …
microbial, and immunomodulatory properties. It is a natural polysaccharide and exudate …
Liquid-like relaxation in hyperquenched water at≤ 140 K
I Kohl, L Bachmann, A Hallbrucker, E Mayer… - Physical Chemistry …, 2005 - pubs.rsc.org
Micrometre-sized water droplets were hyperquenched on a solid substrate held at selected
temperatures between 150 and 77 K. These samples were characterized by differential …
temperatures between 150 and 77 K. These samples were characterized by differential …
Crystallization kinetics and glass-forming ability of rapidly crystallizing drugs studied by Fast Scanning Calorimetry
SE Lapuk, TA Mukhametzyanov, C Schick… - International Journal of …, 2021 - Elsevier
The use of the amorphous forms of drugs is a modern approach for the enhancement of
bioavailability. At the same time, the high cooling rate needed to obtain the metastable …
bioavailability. At the same time, the high cooling rate needed to obtain the metastable …
Glass formation and primary nanocrystallization in Al-base metallic glasses
RI Wu, G Wilde, JH Perepezko - Materials Science and Engineering: A, 2001 - Elsevier
Aluminum-rich metallic glasses containing transition metals and rare earth elements have
been found to yield finely mixed microstructures of Al nanocrystals embedded in an …
been found to yield finely mixed microstructures of Al nanocrystals embedded in an …
Kinetic stability of amorphous solid dispersions with high content of the drug: A fast scanning calorimetry investigation
SE Lapuk, LS Zubaidullina, MA Ziganshin… - International Journal of …, 2019 - Elsevier
Formation of amorphous solid dispersions is an effective way to enhance the bioavailability
of drugs. One of the main disadvantages of such systems is their low storage stability …
of drugs. One of the main disadvantages of such systems is their low storage stability …
Finding the needle in the haystack: characterization of trace crystallinity in a commercial formulation of paclitaxel protein-bound particles by Raman spectroscopy …
PD Schmitt, NS Trasi, LS Taylor… - Molecular …, 2015 - ACS Publications
Second harmonic generation (SHG) microscopy was used to rapidly identify regions of
interest for localized confocal Raman spectroscopy measurements in order to quantify …
interest for localized confocal Raman spectroscopy measurements in order to quantify …