Mannich bases in medicinal chemistry and drug design
G Roman - European journal of medicinal chemistry, 2015 - Elsevier
The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …
compounds that are generated from various substrates through the introduction of an …
4-Thiazolidinones: the advances continue…
AC Tripathi, SJ Gupta, GN Fatima, PK Sonar… - European Journal of …, 2014 - Elsevier
The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …
many researchers to explore this framework for its potential. It is, therefore, of prime …
2, 3-Dihydroquinazolin-4 (1 H)-one as a privileged scaffold in drug design
M Badolato, F Aiello, N Neamati - RSC advances, 2018 - pubs.rsc.org
2, 3-Dihydroquinazolin-4-one (DHQ) belongs to the class of nitrogen-containing heterocyclic
compounds representing a core structural component in various biologically active …
compounds representing a core structural component in various biologically active …
Medicinal perspective of quinazolinone derivatives: Recent developments and structure–activity relationship studies
SK Wahan, B Sharma… - Journal of Heterocyclic …, 2022 - Wiley Online Library
Heterocyclic rings have long piqued the interest of medicinal chemists. Quinazolinone is a
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …
Discovery of a new class of natural product-inspired quinazolinone hybrid as potent antileishmanial agents
M Sharma, K Chauhan, R Shivahare… - Journal of Medicinal …, 2013 - ACS Publications
The high potential of quinazolinone containing natural products and their derivatives in
medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone …
medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone …
Synthesis and Bioactivity Evaluation of Novel Arylimines Containing a 3-Aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone Moiety
X Wang, P Li, Z Li, J Yin, M He, W Xue… - Journal of agricultural …, 2013 - ACS Publications
Twenty-seven novel (E)-3-[2-arylideneaminoethyl]-2-[4-(trifluoromethoxy) anilino]-4 (3 H)-
quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with …
quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with …
Discovery of Alkaloid Quinazolone‐Derived Imidazolenones with Novel Structural Scaffolds of Multitargeting Antibacterial Potential
J Dai, N Battini, ZL Zang, Y Luo… - Chinese Journal of …, 2023 - Wiley Online Library
Comprehensive Summary Alkaloids are one of the prominent members in the development
of new antimicrobial agents. This work discovered a class of alkaloid quinazolone‐derived …
of new antimicrobial agents. This work discovered a class of alkaloid quinazolone‐derived …
Novel thiazolylketenyl quinazolinones as potential anti-MRSA agents and allosteric modulator for PBP2a
J Dai, N Battini, Z Zang, Y Luo, C Zhou - Molecules, 2023 - mdpi.com
Bacterial infections caused by methicillin-resistant Staphylococcus aureus have seriously
threatened public health. There is an urgent need to propose an existing regimen to …
threatened public health. There is an urgent need to propose an existing regimen to …
Recent advances in the transition-metal-free synthesis of quinazolines
R Tamatam, D Shin - Molecules, 2023 - mdpi.com
Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a
variety of natural products and synthetic chemicals with a broad spectrum of biological and …
variety of natural products and synthetic chemicals with a broad spectrum of biological and …
[HTML][HTML] Design, synthesis and structure-activity studies of amino acids conjugated quinazolinone-Schiff's bases as potential antioxidant and anti-inflammatory agents
A novel series of amino acids conjugated quinazolinone-Schiff's bases were synthesized
and characterized by analytical and spectroscopic methods. All the synthesized analogues …
and characterized by analytical and spectroscopic methods. All the synthesized analogues …