Sonic hedgehog (Shh) is a secreted protein that controls the patterning of neural progenitor
cells, and their neuronal and glial progeny, during development. Emerging findings suggest …

Within the dentate gyrus of the adult hippocampus is the subgranular zone, which contains a
neurogenic niche for radial-glia like cells, the most primitive neural stem cells in the adult …

Plasticity of adult neurogenesis supports adaptation to environmental changes. The
identification of molecular mediators that signal these changes to neural progenitors in the …

Cognitive disturbances, mood disorders and fatigue are common in SLE patients with
substantial adverse effects on function and quality of life. Attribution of these clinical findings …

The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells
(NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize …

Brain-derived neurotrophic factor (BDNF) plays an important role in promoting the growth,
differentiation, survival and synaptic stability of neurons. Presently, the transplantation of …

Adult neurogenesis, a developmental process of generating functionally integrated neurons
from neural stem cells, occurs throughout life in the hippocampus of the mammalian brain …

Neural stem cell (NSC) differentiation and proliferation are important biological processes in
the cerebral neural network. However, these two abilities of NSCs are limited. Thus, the …

Data accumulated over the past four decades have confirmed that adult hippocampal
neurogenesis (HN) plays a key role in the wide spectrum of hippocampal pathology …

Background Neural stem cell (NSC) proliferation and differentiation in the mammalian brain
decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult …