Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host
B Singh, C Fleury, F Jalalvand… - FEMS microbiology …, 2012 - academic.oup.com
Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …
Proteases in parasitic diseases
JH McKerrow, C Caffrey, B Kelly… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Parasitic diseases represent major global health problems of immense proportion.
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness …
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness …
[HTML][HTML] Leishmania virulence factors: focus on the metalloprotease GP63
M Olivier, VD Atayde, A Isnard, K Hassani… - Microbes and infection, 2012 - Elsevier
Parasites of Leishmania genus have developed elegant strategies permitting them to evade
the innate immune response upon their initial interaction with macrophages. Their capacity …
the innate immune response upon their initial interaction with macrophages. Their capacity …
The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function
Leishmania sp. are digenetic protozoa that cause an estimated 1.5–2 million new cases of
leishmaniasis per year worldwide. Among the molecular factors that contribute to …
leishmaniasis per year worldwide. Among the molecular factors that contribute to …
Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?
D McMahon‐Pratt, J Alexander - Immunological reviews, 2004 - Wiley Online Library
Parasitic protozoa of the genus Leishmania have provided a useful perspective for
immunologists in terms of host defense mechanisms critical for the resolution of infection …
immunologists in terms of host defense mechanisms critical for the resolution of infection …
Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions
VD Atayde, K Hassani, A da Silva Lira Filho… - Cellular …, 2016 - Elsevier
Leishmania parasites are the causative agents of the leishmaniases, a collection of vector-
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …
Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases
With more than 12 million people affected worldwide, 2 million new cases occurring per
year, and the rapid emergence of drug resistance and treatment failure, leishmaniasis is an …
year, and the rapid emergence of drug resistance and treatment failure, leishmaniasis is an …
Leishmania exosomes/extracellular vesicles containing GP63 are essential for enhance cutaneous leishmaniasis development upon co-inoculation of Leishmania …
A da Silva Lira Filho, EF Fajardo, KP Chang… - Frontiers in cellular …, 2022 - frontiersin.org
Protozoan parasites of the genus Leishmania are transmitted by the bite of infected sand
flies leading to a wide range of diseases called leishmaniasis. Recently, we demonstrated …
flies leading to a wide range of diseases called leishmaniasis. Recently, we demonstrated …
Impact of Leishmania metalloprotease GP63 on macrophage signaling
The intramacrophage protozoan parasites of Leishmania genus have developed
sophisticated ways to subvert the innate immune response permitting their infection and …
sophisticated ways to subvert the innate immune response permitting their infection and …
Cysteine peptidases as virulence factors of Leishmania
JC Mottram, GH Coombs, J Alexander - Current opinion in microbiology, 2004 - Elsevier
Leishmania mexicana amastigotes are particularly rich in cysteine peptidases (CPs), which
play important roles in facilitating the survival and growth of the parasites in mammals. The …
play important roles in facilitating the survival and growth of the parasites in mammals. The …