Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host

B Singh, C Fleury, F Jalalvand… - FEMS microbiology …, 2012 - academic.oup.com
Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Proteases in parasitic diseases

JH McKerrow, C Caffrey, B Kelly… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Parasitic diseases represent major global health problems of immense proportion.
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness …

[HTML][HTML] Leishmania virulence factors: focus on the metalloprotease GP63

M Olivier, VD Atayde, A Isnard, K Hassani… - Microbes and infection, 2012 - Elsevier
Parasites of Leishmania genus have developed elegant strategies permitting them to evade
the innate immune response upon their initial interaction with macrophages. Their capacity …

The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function

C Yao, JE Donelson, ME Wilson - Molecular and biochemical parasitology, 2003 - Elsevier
Leishmania sp. are digenetic protozoa that cause an estimated 1.5–2 million new cases of
leishmaniasis per year worldwide. Among the molecular factors that contribute to …

Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?

D McMahon‐Pratt, J Alexander - Immunological reviews, 2004 - Wiley Online Library
Parasitic protozoa of the genus Leishmania have provided a useful perspective for
immunologists in terms of host defense mechanisms critical for the resolution of infection …

Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions

VD Atayde, K Hassani, A da Silva Lira Filho… - Cellular …, 2016 - Elsevier
Leishmania parasites are the causative agents of the leishmaniases, a collection of vector-
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …

Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases

MA Gomez, I Contreras, M Hallé, ML Tremblay… - Science …, 2009 - science.org
With more than 12 million people affected worldwide, 2 million new cases occurring per
year, and the rapid emergence of drug resistance and treatment failure, leishmaniasis is an …

Leishmania exosomes/extracellular vesicles containing GP63 are essential for enhance cutaneous leishmaniasis development upon co-inoculation of Leishmania …

A da Silva Lira Filho, EF Fajardo, KP Chang… - Frontiers in cellular …, 2022 - frontiersin.org
Protozoan parasites of the genus Leishmania are transmitted by the bite of infected sand
flies leading to a wide range of diseases called leishmaniasis. Recently, we demonstrated …

Impact of Leishmania metalloprotease GP63 on macrophage signaling

A Isnard, MT Shio, M Olivier - Frontiers in cellular and infection …, 2012 - frontiersin.org
The intramacrophage protozoan parasites of Leishmania genus have developed
sophisticated ways to subvert the innate immune response permitting their infection and …

Cysteine peptidases as virulence factors of Leishmania

JC Mottram, GH Coombs, J Alexander - Current opinion in microbiology, 2004 - Elsevier
Leishmania mexicana amastigotes are particularly rich in cysteine peptidases (CPs), which
play important roles in facilitating the survival and growth of the parasites in mammals. The …