A complex network of chemokines and their receptors influences the development of primary
tumours and metastases. New information about the biological role of chemokines in these …

Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the
bone marrow. The stem cell niche is thought to provide signals that support key HSC …

Classically considered short-lived and purely defensive leukocytes, neutrophils are unique
in their fast and moldable response to stimulation. This plastic behavior may underlie …

Skeletal stem cells regulate bone growth and homeostasis by generating diverse cell types,
including chondrocytes, osteoblasts and marrow stromal cells. The emerging concept …

Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations
underpinning the major functions of the skeleton, a majority of which adjoin sinusoidal blood …

Arterioles and sinusoids of the bone marrow (BM) are accompanied by stromal cells that
express nerve/glial antigen 2 (NG2) and leptin receptor (LepR), and constitute specialized …

Haematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals
generated by stromal cells regulate their self-renewal, proliferation and trafficking. Endosteal …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

Germinal center (GC) dark and light zones segregate cells undergoing somatic
hypermutation and antigen-driven selection, respectively, yet the factors guiding this …

Lympho–stromal interactions in multiple microenvironments within the thymus have a crucial
role in the regulation of T-cell development and selection. Recent studies have implicated …