Sex differences in traumatic brain injury: what we know and what we should know

RP Gupte, WM Brooks, RR Vukas, JD Pierce… - Journal of …, 2019 - liebertpub.com
There is growing recognition of the problem of male bias in neuroscience research,
including in the field of traumatic brain injury (TBI) where fewer women than men are …

[HTML][HTML] Measuring anxiety-like behaviors in rodent models of traumatic brain injury

LB Tucker, JT McCabe - Frontiers in behavioral neuroscience, 2021 - frontiersin.org
Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the
measurement of dysfunctional anxiety behavioral states following experimental TBI in …

Sexual dimorphism in the inflammatory response to traumatic brain injury

S Villapol, DJ Loane, MP Burns - Glia, 2017 - Wiley Online Library
The activation of resident microglial cells, alongside the infiltration of peripheral
macrophages, are key neuroinflammatory responses to traumatic brain injury (TBI) that are …

[HTML][HTML] Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

H Abou-El-Hassan, RM Rezende, S Izzy… - Nature …, 2023 - nature.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

Sex differences in acute neuroinflammation after experimental traumatic brain injury are mediated by infiltrating myeloid cells

SJ Doran, RM Ritzel, EP Glaser, RJ Henry… - Journal of …, 2019 - liebertpub.com
The inflammatory response to moderate-severe controlled cortical impact (CCI) in adult male
mice has been shown to exhibit greater glial activation compared with age-matched female …

[HTML][HTML] Behavior of male and female C57BL/6J mice is more consistent with repeated trials in the elevated zero maze than in the elevated plus maze

LB Tucker, JT McCabe - Frontiers in behavioral neuroscience, 2017 - frontiersin.org
The elevated plus maze (EPM) and elevated zero maze (EZM) are behavioral tests that are
widely employed to assess anxiety-like behaviors in rats and mice following experimental …

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

BD Semple, A Zamani, G Rayner, SR Shultz… - Neurobiology of …, 2019 - Elsevier
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive,
psychological, and psychosocial deficits that can have a profound impact on an individual's …

[HTML][HTML] Endocannabinoids: a promising impact for traumatic brain injury

LD Schurman, AH Lichtman - Frontiers in pharmacology, 2017 - frontiersin.org
The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of
physiological processes and unsurprisingly possesses considerable potential targets for the …

[HTML][HTML] Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation …

M Hanscom, DJ Loane, T Aubretch, J Leser… - Journal of …, 2021 - Springer
Background Disruptions of brain-gut axis have been implicated in the progression of a
variety of gastrointestinal (GI) disorders and central nervous system (CNS) diseases and …

[HTML][HTML] The closed-head impact model of engineered rotational acceleration (CHIMERA) as an application for traumatic brain injury pre-clinical research: a status …

EH McNamara, AA Grillakis, LB Tucker… - Experimental neurology, 2020 - Elsevier
Closed-head traumatic brain injury (TBI) is a worldwide concern with increasing prevalence
and cost to society. Rotational acceleration is a primary mechanism in TBI that results from …