Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines
expressed in many different cell types including skeletal muscle. Members of this …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

In striated muscle sarcomeres, the contractile actin and myosin filaments are organised by a
subset of specialised cytoskeletal proteins, the sarcomeric cytoskeleton. They include α …

The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …

Titin, the giant elastic ruler protein of striated muscle sarcomeres, contains a catalytic kinase
domain related to a family of intrasterically regulated protein kinases. The most extensively …

Background Growth is a major economic production trait in aquaculture. Improvements in
growth performance will reduce time and cost for fish to reach market size. However, genes …

Rationale: Telethonin (also known as titin-cap or t-cap) is a 19-kDa Z-disk protein with a
unique β-sheet structure, hypothesized to assemble in a palindromic way with the N-terminal …

Juvenile idiopathic arthritis (JIA) is an autoimmune, inflammatory joint disease with complex
genetic etiology. Previous GWAS have found many genetic loci associated with JIA …

Alternative splicing has emerged as a fundamental mechanism for the spatiotemporal
control of development. A better understanding of how this mechanism is regulated has the …