Ovarian cancer (OC) is one of the most common gynecologic tumors worldwide and one
with the highest mortality. Cisplatin (DDP) is the first platinum-based complex approved by …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Research in the field of bioinorganic chemistry has been stimulated by the worldwide
success of the anticancer drug cisplatin. 40 years after the first report about its biological …

The application of inorganic chemistry to medicine is a rapidly developing field, and novel
therapeutic and diagnostic metal complexes are now having an impact on medical practice …

DNA is believed to be the primary target for many metal-based drugs. For example, platinum-
based anticancer drugs can form specific lesions on DNA that induce apoptosis. New …

The platinum antitumor drugs cisplatin, carboplatin and oxaliplatin are widely used
components of modern cancer chemotherapy. However, their success is limited by severe …

Sulfur manifests its influence on platinum anticancer chemotherapy in two aspects:
endogenous sulfurcontaining molecules such as cysteine, methionine, glutathione …

Cisplatin, carboplatin and oxaliplatin are anticancer drugs, which are efficiently used in the
clinics all over the world. Besides a remarkable therapeutic efficacy in a series of solid …

A series of bis (carboxylato) dichlorido (ethane-1, 2-diamine) platinum (IV) compounds with
IC50 values ranging between 142μM and 18nM was investigated with respect to their …

Cisplatin and its platinum (Pt)(II) derivatives play a key role in the fight against various
human cancers such as testicular, ovarian, head and neck, lung tumors. However, their …