▪ Abstract Cells have high-fidelity polymerases whose task is to accurately replicate the
genome, and low-fidelity polymerases with specialized functions. Although some of these …

It is of paramount importance to biological organisms that their genetic information be
preserved in an intact, replicable state to maintain and perpetuate their existence. However …

Mammalian DNA polymerase (pol) λ is a member of the X-family of DNA polymerases and
has striking enzymatic and structural similarities to mammalian DNA pol β. Because pol β …

During cell division, replication of the genomic DNA is performed by high-fidelity DNA
polymerases but these error-free enzymes can not synthesize across damaged DNA …

DNA polymerases (pols) catalyse the synthesis of DNA. This reaction requires a primer-
template DNA in order to grow from the 3′ OH end of the primer along the template. On the …

The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The
rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity …

Little is known about the functions of DNA polymerase λ (Pol λ) recently identified in
mammals. From the genomic sequence information of rice and Arabidopsis, we found that …

Proliferating cell nuclear antigen (PCNA) has been shown to interact with a variety of DNA
polymerases (pol) such as pol δ, pol ε, pol ι, pol κ, pol η, and pol β. Here we show that PCNA …

Synthesis of the genetic material of the cell is achieved by a large number of DNA
polymerases. Besides replicating the genome, they are involved in DNA-repair processes …

Maintenance of the information embedded in the genomic DNA sequence is essential for
life. DNA polymerases play pivotal roles in the complex processes that maintain genetic …