Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience

LJ Lissner, KM Wartchow, AP Toniazzo… - Pharmacology …, 2021 - Elsevier
Object recognition (OR) and the Morris water maze (MWM) are classical tasks widely used to
assess memory parameters and deficits in rodents. Learning processes in both tasks involve …

Risks of cognitive detriments after low dose heavy ion and proton exposures

FA Cucinotta, E Cacao - International journal of radiation biology, 2019 - Taylor & Francis
Purpose: Heavy ion and proton brain irradiations occur during space travel and in Hadron
therapy for cancer. Heavy ions produce distinct patterns of energy deposition in neuron cells …

[HTML][HTML] Fecal microbiota transplantation reduces pathology and improves cognition in a mouse model of Alzheimer's disease

S Elangovan, TJ Borody, RMD Holsinger - Cells, 2022 - mdpi.com
Characterized by the presence of amyloid plaques, neurofibrillary tangles and
neuroinflammation, Alzheimer's disease (AD) is a progressive neurodegenerative disorder …

[HTML][HTML] The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy …

E Pajarillo, S Kim, A Digman, M Dutton, DS Son… - Journal of Biological …, 2023 - ASBMB
Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing
common symptoms with Parkinson's disease (PD). Studies have shown that Mn can …

[HTML][HTML] Genetic predisposition to Alzheimer's disease alters inflammasome activity after traumatic brain injury

NH Johnson, NA Kerr, JP de Rivero Vaccari… - Translational …, 2023 - Elsevier
Abstract Traumatic Brain Injury (TBI) is a major cause of death and disability in the US and a
recognized risk factor for the development of Alzheimer's disease (AD). The relationship …

[HTML][HTML] Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder

R Paterno, JR Marafiga, H Ramsay, T Li, KA Salvati… - Cell reports, 2021 - cell.com
Impaired synaptic neurotransmission may underly circuit alterations contributing to
behavioral autism spectrum disorder (ASD) phenotypes. A critical component of impairments …

Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

JM Hafycz, E Strus, N Naidoo - Aging Cell, 2022 - Wiley Online Library
As the aging population grows, the need to understand age‐related changes in health is
vital. Two prominent behavioral changes that occur with age are disrupted sleep and …

Protective effects of apigenin on the brain transcriptome with aging

AN Cavalier, ZS Clayton, D Wahl, DA Hutton… - Mechanisms of Ageing …, 2024 - Elsevier
Brain aging is associated with reduced cognitive function that increases the risk for
dementia. Apigenin is a bioactive plant compound that inhibits cellular aging processes and …

[HTML][HTML] The impact of probiotic supplementation on cognitive, pathological and metabolic markers in a transgenic mouse model of Alzheimer's disease

TS Webberley, G Masetti, RJ Bevan… - Frontiers in …, 2022 - frontiersin.org
Brain degenerative disorders such as Alzheimer's disease (AD) can be exacerbated by
aberrant metabolism. Supplementation with probiotic bacteria is emerging as a promising …

[HTML][HTML] Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal …

E Díaz-Sánchez, A López-Salas… - Biomedicine & …, 2023 - Elsevier
Different brain regions' interactions have been implicated in relevant neurological diseases,
such as major depressive disorder (MDD), anxiety disorders, age-dependent cognitive …