Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair
The duplication of the eukaryotic genome is an intricate process that has to be tightly safe‐
guarded. One of the most frequently occurring errors during DNA synthesis is the mis …
guarded. One of the most frequently occurring errors during DNA synthesis is the mis …
Mechanisms of damage tolerance and repair during DNA replication
ME Ashour, N Mosammaparast - Nucleic acids research, 2021 - academic.oup.com
Accurate duplication of chromosomal DNA is essential for the transmission of genetic
information. The DNA replication fork encounters template lesions, physical barriers …
information. The DNA replication fork encounters template lesions, physical barriers …
[HTML][HTML] Endogenous DNA 3′ blocks are vulnerabilities for BRCA1 and BRCA2 deficiency and are reversed by the APE2 nuclease
A Álvarez-Quilón, JL Wojtaszek, MC Mathieu, T Patel… - Molecular cell, 2020 - cell.com
The APEX2 gene encodes APE2, a nuclease related to APE1, the apurinic/apyrimidinic
endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated …
endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated …
APE1 senses DNA single-strand breaks for repair and signaling
DNA single-strand breaks (SSBs) represent the most abundant type of DNA damage.
Unrepaired SSBs impair DNA replication and transcription, leading to cancer and …
Unrepaired SSBs impair DNA replication and transcription, leading to cancer and …
Functional importance and divergence of plant apurinic/apyrimidinic endonucleases in somatic and meiotic DNA repair
J Li, C Wang, W Liang, J Zhang, CK Jiang, Y Liu… - The Plant …, 2023 - academic.oup.com
Apurinic/apyrimidinic (AP) sites are one of the most abundant DNA lesions and are mainly
repaired by AP endonucleases (APEs). While most eukaryotic genomes encode two APEs …
repaired by AP endonucleases (APEs). While most eukaryotic genomes encode two APEs …
Mechanisms of DNA− protein cross-link formation and repair
Covalent binding of DNA to proteins produces DNA− protein cross-links (DPCs). DPCs are
formed as intermediates of enzymatic processes, generated from the reactions of protein …
formed as intermediates of enzymatic processes, generated from the reactions of protein …
[HTML][HTML] Signatures of TOP1 transcription-associated mutagenesis in cancer and germline
The mutational landscape is shaped by many processes. Genic regions are vulnerable to
mutation but are preferentially protected by transcription-coupled repair. In microorganisms …
mutation but are preferentially protected by transcription-coupled repair. In microorganisms …
Ribonucleotide incorporation into DNA during DNA replication and its consequences
Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their
vast presence and influence over genome biology is becoming increasingly appreciated …
vast presence and influence over genome biology is becoming increasingly appreciated …
How RNA impacts DNA repair
The central dogma of molecular biology posits that genetic information flows unidirectionally,
from DNA, to RNA, and finally to protein. However, this directionality is broken in some …
from DNA, to RNA, and finally to protein. However, this directionality is broken in some …
[HTML][HTML] USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease
DNA–protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic
processes such as replication, transcription, and recombination. USP11 deubiquitinase …
processes such as replication, transcription, and recombination. USP11 deubiquitinase …