The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases

N Lubben, E Ensink, GA Coetzee… - Brain …, 2021 - academic.oup.com
The lateralization of the human brain may provide clues into the pathogenesis and
progression of neurodegenerative diseases. Though differing in their presentation and …

Lateralisation in Parkinson disease

P Riederer, KA Jellinger, P Kolber, G Hipp… - Cell and tissue …, 2018 - Springer
Asymmetry of dopaminergic neurodegeneration and subsequent lateralisation of motor
symptoms are distinctive features of Parkinson's disease compared to other forms of …

[HTML][HTML] Predictive markers for Parkinson's disease using deep neural nets on neuromelanin sensitive MRI

S Shinde, S Prasad, Y Saboo, R Kaushick, J Saini… - NeuroImage: Clinical, 2019 - Elsevier
Neuromelanin sensitive magnetic resonance imaging (NMS-MRI) has been crucial in
identifying abnormalities in the substantia nigra pars compacta (SNc) in Parkinson's disease …

Digitized spiral drawing: A possible biomarker for early Parkinson's disease

M San Luciano, C Wang, RA Ortega, Q Yu… - PloS one, 2016 - journals.plos.org
Introduction Pre-clinical markers of Parkinson's Disease (PD) are needed, and to be relevant
in pre-clinical disease, they should be quantifiably abnormal in early disease as well …

[HTML][HTML] Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the …

N He, K Ghassaban, P Huang, M Jokar, Y Wang… - Neuroimage, 2021 - Elsevier
Diagnosing early stage Parkinson's disease (PD) is still a clinical challenge. Previous
studies using iron, neuromelanin (NM) or the Nigrosome-1 (N1) sign in the substantia nigra …

Cortical asymmetry in Parkinson's disease: early susceptibility of the left hemisphere

DO Claassen, KE McDonell, M Donahue… - Brain and …, 2016 - Wiley Online Library
Abstract Background and Purpose Clinically, Parkinson's disease (PD) presents with
asymmetric motor symptoms. The left nigrostriatal system appears more susceptible to early …

Dopamine transporter imaging, current status of a potential biomarker: A comprehensive review

G Palermo, S Giannoni, G Bellini, G Siciliano… - International Journal of …, 2021 - mdpi.com
A major goal of current clinical research in Parkinson's disease (PD) is the validation and
standardization of biomarkers enabling early diagnosis, predicting outcomes, understanding …

Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's disease

C Scherfler, K Seppi, KJ Mair, E Donnemiller, I Virgolini… - Brain, 2012 - academic.oup.com
The aim of this study was to investigate the distribution and the degree of asymmetric
putaminal dopamine transporter availability in right-handed patients with Parkinson's …

[HTML][HTML] Disruption of posterior brain functional connectivity and its relation to cognitive impairment in idiopathic REM sleep behavior disorder

A Campabadal, A Abós, B Segura, M Serradell… - NeuroImage: Clinical, 2020 - Elsevier
Background Resting-state functional MRI has been proposed as a new biomarker of
prodromal neurodegenerative disorders, but it has been poorly investigated in the idiopathic …

Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease

MD Mendonça, PC Ferreira, F Oliveira… - npj Parkinson's …, 2024 - nature.com
Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to
the dopaminergic system. We analysed data from 432 subjects from the Parkinson's …