Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg
ulcers, and pressure ulcers. They are a challenge to wound care professionals and …

The importance of proper skin wound healing becomes evident when our body's repair
mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair …

Vacuum-assisted closure (VAC), sometimes referred to as microdeformational wound
therapy (MDWT) or negative pressure wound therapy (NPWT), has revolutionized wound …

Negative pressure wound therapy (NPWT) promotes healing by evenly applying negative
pressure on the surface of the wound. The system consists of a sponge, a semiocclusive …

Introduction: Aberrant wound healing is a significant healthcare problem, posing a
substantial burden on patients, their families, and the healthcare system. Existing treatment …

The traditional reconstructive ladder has withstood the test of time, serving as a thought
paradigm to guide surgeons in choosing their method of wound closure for an assortment of …

Background Negative-pressure wound therapy (NPWT) promotes angiogenesis and
granulation, in part by strain-induced production of growth factors and cytokines. As their …

It has long been thought that the effectiveness and efficiency of physical therapy would
improve if our understanding of the cell biology/biochemistry that participates in mechanics …

An expert panel carried out a selected review of published literature regarding the
mechanisms of action of the VAC device in the context of published clinical studies. The …

Background: Mechanical forces play an important role in tissue neovascularization and are
a constituent part of modern wound therapies. The mechanisms by which vacuum assisted …