Time-of-flight (TOF) PET was initially introduced in the early days of PET. The TOF PET
scanners developed in the 1980s had limited sensitivity and spatial resolution, were …

In emission tomography statistically based iterative methods can improve image quality
relative to analytic image reconstruction through more accurate physical and statistical …

Significant improvements have made it possible to add the technology of time-of-flight (TOF)
to improve PET, particularly for oncology applications. The goals of this work were to …

This paper provides a review and an update on time-of-flight PET imaging with a focus on
PET instrumentation, ranging from hardware design to software algorithms. We first present …

Brain PET in small structures is challenged by low resolution inducing bias in the activity
measurements. Improved spatial resolution may be obtained by using dedicated …

Emission computed tomography (ECT) is a technology for medical imaging whose
importance is increasing rapidly. There is a growing appreciation for the value of the …

High-resolution three-dimensional (3-D) positron emission tomography (PET) scanners with
high count rate performance, such as the quad-high density avalanche chamber (HIDAC) …

Methodology for PET system modeling using image-space techniques in the expectation
maximization (EM) algorithm is presented. The approach, applicable to both list-mode data …

Iterative reconstruction algorithms produce accurate images without streak artifacts as in
filtered backprojection. They allow improved incorporation of important corrections for image …

In this article, the authors review novel techniques in the emerging field of spatiotemporal
four‐dimensional (4D) positron emission tomography (PET) image reconstruction. The …