Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly
upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and …

Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …

Recent advances in the understanding of the molecular mechanisms underlying cancer
progression have led to the development of novel therapeutic targeting strategies. Aberrant …

Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a
potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated …

Background Breast cancer (BC) is a complex disease with various subtypes and genetic
alterations that impact DNA repair pathways. Understanding these pathways is essential for …

The tumor–immune microenvironment (TIME) is a critical determinant of therapeutic
response. However, the mechanisms regulating its modulation are not fully understood …

Immunotherapy is a hot area in cancer treatment, and one of the keys to this therapy is the
identification of the right tumour-associated or tumour-specific antigen. Cluster of …

Clinical trials examining broad-spectrum Src family kinase (SFK) inhibitors revealed
significant dose-limiting toxicities, preventing advancement for solid tumors. SFKs are …

Purpose Cancer treatments often become ineffective because of acquired drug resistance.
To characterize changes in breast cancer cells accompanying development of resistance to …

Objectives: Ovarian tumor (OTU) domain-containing ubiquitin aldehyde-binding protein
Otubain2 (OTUB2) is an important cysteine protease with deubiquitinase activity in the OTU …