The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis
(ALS). Here, through a combination of RNA-Seq and electrophysiological studies on …

Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic
lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) …

In this project we set up a human cell‐based DNTin vitro testing strategy that is based on test
methods with high readiness and data generated therefrom. The methods underwent afit‐for …

Abstract In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and
spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore …

Myelination is essential for central nervous system (CNS) formation, health, and function.
Emerging evidence of oligodendrocyte heterogeneity in health and disease and divergent …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …

A growing body of evidence suggests that a loss of chromosome 9 open reading frame 72
(C9ORF72) expression, formation of dipeptide-repeat proteins, and generation of RNA foci …