The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed
chronic symptoms lasting weeks or months which are very similar to those described for …

Postoperative atrial fibrillation (POAF) is a common, expensive and potentially morbid
complication following cardiac surgery. POAF occurs in around 35% of cardiac surgery …

Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver,
alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at …

Significance: Oxidative stress is thought to account for aberrant redox homeostasis and
contribute to aging and disease. However, more often than not, administration of …

Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart
failure, and other cardiovascular diseases, as well, but no therapies are available to treat …

To increase the efficacy of radiation, iron oxide nanoparticles can be utilized for their ability
to produce reactive oxygen species (ROS). Radiation therapy promotes leakage of electrons …