Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

Amyloid precursor protein (APP) is a transmembrane precursor protein that is widely
expressed in the central nervous system and peripheral tissues in the liver and pancreas …

Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD).
Decades of research describe a relationship between mitochondrial function and Aβ …

Osteoporosis and Alzheimer's disease (AD) are both degenerative diseases. Osteoporosis
often proceeds cognitive deficits, and multiple studies have revealed common triggers that …

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
clinical decline in memory and other cognitive functions. A classic AD neuropathological …

Introduction Fasting glucose increases with age and is linked to modifiable Alzheimer's
disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D). Methods We …

Amyloid precursor protein (APP), secretase enzymes, and amyloid beta (Aβ) have been
extensively studied in the context of Alzheimer's disease (AD). Despite this, the function of …

Objective β-secretase/β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is
a key enzyme involved in Alzheimer's disease that has recently been implicated in insulin …

Obesity places an enormous medical and economic burden on society. The principal driver
appears to be central leptin resistance with hyperleptinemia. Accordingly, a compound that …

The amyloid precursor protein (APP) has been extensively investigated for its role in the
production of amyloid beta (Aβ), a plaque-forming peptide in Alzheimer's disease (AD) …