Calcium signaling and exocytosis in adrenal chromaffin cells
AG García, AM García-De-Diego… - Physiological …, 2006 - journals.physiology.org
At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …
Calcium-dependent regulation of exocytosis
A rapid increase in intracellular calcium directly triggers regulated exocytosis. In addition,
changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal …
changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal …
[HTML][HTML] Selective activation of cognate SNAREpins by Sec1/Munc18 proteins
J Shen, DC Tareste, F Paumet, JE Rothman, TJ Melia - Cell, 2007 - cell.com
Summary Sec1/Munc18 (SM) proteins are required for every step of intracellular membrane
fusion, but their molecular mechanism of action has been unclear. In this work, we …
fusion, but their molecular mechanism of action has been unclear. In this work, we …
STXBP1 mutations in early infantile epileptic encephalopathy with suppression‐burst pattern
Purpose: De novo STXBP1 mutations have been found in individuals with early infantile
epileptic encephalopathy with suppression‐burst pattern (EIEE). Our aim was to delineate …
epileptic encephalopathy with suppression‐burst pattern (EIEE). Our aim was to delineate …
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE–Sec1/Munc18 membrane fusion complex
Intracellular membrane fusion is mediated by the concerted action of N-ethylmaleimide-
sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins …
sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins …
Core proteins of the secretory machinery
T Lang, R Jahn - Pharmacology of neurotransmitter release, 2008 - Springer
Members of the Rab, SM-and SNARE-protein families play key roles in all intracellular
membrane trafficking steps. While SM-and SNARE-proteins become directly involved in the …
membrane trafficking steps. While SM-and SNARE-proteins become directly involved in the …
Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming
A Gulyás-Kovács, H de Wit, I Milosevic… - Journal of …, 2007 - Soc Neuroscience
Exocytosis of secretory or synaptic vesicles is executed by a mechanism including the
SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins …
SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins …
Regulation of exocytosis by protein kinase C
PKC (protein kinase C) has been known for many years to modulate regulated exocytosis in
a wide variety of cell types. In neurons and neuroendocrine cells, PKC regulates several …
a wide variety of cell types. In neurons and neuroendocrine cells, PKC regulates several …
Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function
AR Paciorkowski, LL Thio, JA Rosenfeld… - European Journal of …, 2011 - nature.com
Infantile spasms (ISS) are an epilepsy disorder frequently associated with severe
developmental outcome and have diverse genetic etiologies. We ascertained 11 subjects …
developmental outcome and have diverse genetic etiologies. We ascertained 11 subjects …
The synaptic vesicle proteome
J Burré, W Volknandt - Journal of neurochemistry, 2007 - Wiley Online Library
Synaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane‐
associated proteins mediate the various functions the organelle fulfills during its life cycle …
associated proteins mediate the various functions the organelle fulfills during its life cycle …