Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …

In neurons, Glycogen Synthase Kinase‐3β (GSK‐3β) has been shown to regulate various
critical processes underlying structural and functional synaptic plasticity. Mouse models with …

Few things can be considered to be more important to a cell than its threshold for apoptotic
cell death, which can be modulated up or down, but rarely in both directions, by a single …

Protein kinases are a growing drug target class in disorders in peripheral tissues, but the
development of kinase-targeted therapies for central nervous system (CNS) diseases …

Abstract Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating
diverse cellular functions including metabolism, transcription and cell survival. Numerous …

Both thymoquinone (TQ) and thymol (T) have been proved to possess a positive impact on
human health. In this research, we aimed to investigate the effect of these compounds …

Activation of the Akt/protein kinase B (PKB) kinase pathway can be neuroprotective after
stroke. Akt is activated by growth factors via a phosphorylation-dependent pathway involving …

Reoxygenation following ischemia causes tissue oxidative stress. We studied the role of
oxidative stress caused by kidney ischemia/reperfusion (I/R) on the mitochondria of renal …

The mood stabilizer lithium inhibits glycogen synthase kinase-3 (GSK-3) directly or indirectly
by enhancing serine phosphorylation of both α and β isoforms. Lithium robustly protected …