[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives

H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

MP Vincent, JO Navidzadeh, S Bobbala, EA Scott - Cancer Cell, 2022 - cell.com
Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …

Promoting Re-epithelialization in an oxidative diabetic wound microenvironment using self-assembly of a ROS-responsive polymer and P311 peptide micelles

R Shi, H Li, X Jin, X Huang, Z Ou, X Zhang, G Luo… - Acta Biomaterialia, 2022 - Elsevier
Engineering smart nano-therapeutics for re-epithelialisation of chronic wounds facilitates the
wound healing process. However, due to excessive oxidative stress damage and persistent …

An insight on ophthalmic drug delivery systems: focus on polymeric biomaterials-based carriers

M Shafiq, M Rafique, Y Cui, L Pan, CW Do… - Journal of Controlled …, 2023 - Elsevier
Presently, different types of eye diseases, such as glaucoma, myopia, infection, and dry eyes
are treated with topical eye drops. However, due to ocular surface barriers, eye drops …

Breaking barriers in eye treatment: Polymeric nano-based drug-delivery system for anterior segment diseases and glaucoma

KY Wu, S Ashkar, S Jain, M Marchand, SD Tran - Polymers, 2023 - mdpi.com
The eye has anatomical structures that function as robust static and dynamic barriers,
limiting the penetration, residence time, and bioavailability of medications administered …

Assessing the Steric Impact of Surface Ligands on the Proteolytic Turnover of Quantum Dot–Peptide Conjugates

KD Krause, K Rees, WR Algar - ACS Applied Materials & …, 2023 - ACS Publications
Proteases are important biomarkers and targets for the diagnosis and treatment of disease.
The advantageous properties of semiconductor quantum dots (QDs) have made these …

Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides, and proteins

Y Tian, MV Tirrell, JL LaBelle - Advanced healthcare materials, 2022 - Wiley Online Library
Biomacromolecules have long been at the leading edge of academic and pharmaceutical
drug development and clinical translation. With the clinical advances of new therapeutics …

Nanocarriers for targeted drug delivery in the vascular system: Focus on endothelium

X Cong, Z Zhang, H Li, YG Yang, Y Zhang… - Journal of …, 2024 - Springer
Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics,
and modulating inflammatory responses. Nanocarriers hold transformative potential for …

Nanomaterials in the diagnosis and treatment of ophthalmic diseases

Y Ma, Z Zhang, Y Yu, X Wang, S Liu, B Sun, Z Cai… - Nano Today, 2024 - Elsevier
The complexity of the human eye structure poses challenges in the diagnosis and treatment
of ocular diseases, especially the low efficiency of ocular drug delivery. With the continuous …

Fostering the unleashing potential of nanocarriers-mediated delivery of ocular therapeutics

D Datta, SP Bandi, V Colaco, N Dhas… - International Journal of …, 2024 - Elsevier
Ocular delivery is the most challenging aspect in the field of pharmaceutical research. The
major hurdle for the controlled delivery of drugs to the eye includes the physiological static …