Understanding the concept of pre-clinical autoimmunity: prediction and prevention of systemic lupus erythematosus: identifying risk factors and developing strategies …

MY Choi, KH Costenbader - Frontiers in immunology, 2022 - frontiersin.org
There is growing evidence that preceding the diagnosis or classification of systemic lupus
erythematosus (SLE), patients undergo a preclinical phase of disease where markers of …

Differential impact of environmental factors on systemic and localized autoimmunity

H Touil, K Mounts, PL De Jager - Frontiers in immunology, 2023 - frontiersin.org
The influence of environmental factors on the development of autoimmune disease is being
broadly investigated to better understand the multifactorial nature of autoimmune …

Interactions between genetic risk and diet influencing risk of incident female gout: discovery and replication analysis of four prospective cohorts

K Lin, N McCormick, C Yokose, AD Joshi… - Arthritis & …, 2023 - Wiley Online Library
Objective To examine whether the cross‐sectional gene–diet interaction for prevalent
hyperuricemia among women translates prospectively to risk of incident female gout …

Environment and systemic autoimmune rheumatic diseases: an overview and future directions

MY Choi, KH Costenbader, MJ Fritzler - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Despite progress in our understanding of disease pathogenesis for systemic
autoimmune rheumatic diseases (SARD), these diseases are still associated with high …

Risk prediction models for incident systemic lupus erythematosus among women in the nurses' health study cohorts using genetics, family history, and lifestyle and …

J Cui, S Malspeis, MY Choi, B Lu, JA Sparks… - Seminars in arthritis and …, 2023 - Elsevier
Objective Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease
that predominantly affects women. Its etiology is complex and multifactorial, with several …

The role of environmental exposures and gene–environment interactions in the etiology of systemic lupus erythematous

JMP Woo, CG Parks, S Jacobsen… - Journal of Internal …, 2022 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease, whose
etiology includes both genetic and environmental factors. Individual genetic risk factors likely …

[HTML][HTML] Cholesterol-rich dietary pattern during early pregnancy and genetic variations of cholesterol metabolism genes in predicting gestational diabetes mellitus: a …

N Cui, Y Li, S Huang, Y Ge, S Guo, L Tan, L Hao… - The American Journal of …, 2023 - Elsevier
Background Higher dietary cholesterol intake during pregnancy increases risk of gestational
diabetes mellitus (GDM). However, no studies have investigated interindividual variability in …

Impact of adiposity on risk of female gout among those genetically predisposed: sex-specific prospective cohort study findings over> 32 years

N McCormick, C Yokose, N Lu, AD Joshi… - Annals of the …, 2022 - ard.bmj.com
Objectives To evaluate the joint (combined) association of excess adiposity and genetic
predisposition with the risk of incident female gout, and compare to their male counterparts; …

Abnormal mitochondrial physiology in the pathogenesis of systemic lupus erythematosus

C Wincup, A Radziszewska - Rheumatic Disease Clinics, 2021 - rheumatic.theclinics.com
Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune condition
characterized by the formation for autoantibodies directed against nuclear components. 1 …

Environment, Lifestyles, and Climate Change: The Many Nongenetic Contributors to The Long and Winding Road to Autoimmune Diseases

FW Miller - Arthritis Care & Research, 2025 - Wiley Online Library
A critical unanswered question is what is causing the increase in the prevalence of
autoimmunity and autoimmune diseases around the world. Given the rapidity of change, this …