Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Highlights•Image-based profiling uses hundreds of measurements of cell morphology from
images.•Samples with similar phenotypes are grouped based on this unbiased, quantitative …

Profiling approaches such as gene expression or proteome profiling generate small-
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …

A rise in resistance to current antifungals necessitates strategies to identify alternative
sources of effective fungicides. We report the discovery of poacic acid, a potent antifungal …

Visual observation is a powerful approach for screening bioactive compounds that can
facilitate the discovery of attractive druggable targets following their chemicobiological …

Cell morphological phenotypes, including shape, size, intensity, and texture of cellular
compartments have been shown to change in response to perturbation with small molecule …

Synthetic biology has played a major role in engineering microbial cell factories to convert
plant biomass (lignocellulose) to fuels and bioproducts by fermentation. However, the final …

Unbiased profiling approaches are powerful tools for small-molecule target or mode-of-
action deconvolution as they generate a holistic view of the bioactivity space. This is …

Vanillin, generated by acid hydrolysis of lignocellulose, acts as a potent inhibitor of the
growth of the yeast Saccharomyces cerevisiae. Here, we investigated the cellular processes …

Recently, a phenotypic approach—screens that assess the effects of compounds on cells,
tissues, or whole organisms—has been reconsidered and reintroduced as a complementary …