Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Childhood obesity is a major public health problem worldwide, and the relationship between
obesity and central precocious puberty has long been confirmed, however, the mechanisms …

Current pharmacological therapies for treating obesity are of limited efficacy. Genetic
ablation or loss of function of AMP-activated protein kinase alpha 1 (AMPKα1) in …

Sex differences are found across brain regions, behaviors, and brain diseases. Sexual
differentiation of the brain is initiated prenatally but it continues throughout life, as a result of …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

The onset of puberty and the female ovulatory cycle are important developmental milestones
of the reproductive system. These processes are controlled by a tightly organized network of …

Puberty is a major maturational event; its mechanisms and timing are driven by genetic
determinants, but also controlled by endogenous and environmental cues. Substantial …

Sexual maturation in humans is characterized by a unique individual variability. Pubertal
onset is a highly heritable polygenic trait but it is also affected by environmental factors such …

Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked
to higher disease burden later in life. The mechanisms underlying this association remain …

Background: The effects of endocrine-disrupting chemicals (EDCs) on fertility and
reproductive development represent a rising concern in modern societies. Although the …