Parkinson's disease (PD) is a neurological disorder marked by the presence of cytoplasmic
inclusions, Lewy bodies (LBs) and Lewy neurites (LNs) as well as the degeneration of …

In familial neurodegenerative disorders, protein aggregates form continuously because of
genetic mutations that drive the synthesis of truncated or unfolded proteins. The oxidative …

Parkinson's disease (PD) is a growing burden worldwide, and there is no reliable biomarker
used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients …

Personalized medicine promises individualized disease prediction and treatment. The
convergence of machine learning (ML) and available multimodal data is key moving …

Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin
D manages protein turnover degrading misfolded and aggregated proteins and favors …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

Previous studies on Parkinson's disease mechanisms have shown dysregulated
extracellular transport of α-synuclein and growth factors in the extracellular space. In the …

We aimed to explore the mechanism of pramipexole (PPX) actions in the treatment of
Parkinson's disease (PD). Genes related to PD and PPX were screened through …

Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) are symptomatically
characterized by parkinsonism, with the latter presenting additionally a distinctive range of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …