Novel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating
dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and …

Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …

Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol
use disorders are phenotypically complex and heritable. The heritability of alcohol use …

Objectives Repetitive transcranial magnetic stimulation (rTMS) is a potential therapeutic
intervention for the treatment of addiction. This critical review aims to summarise the recent …

Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Animal models have been widely used to gain insight into the mechanisms underlying the
acute and long-term effects of alcohol exposure. The fruit fly Drosophila melanogaster …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …

Alcohol dependence encompasses a serious medical and societal problem that constitutes
a major public health concern. A serious consequence of dependence is the emergence of …