The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …

Gene expression is modulated by both physiological signals (hormones, cytokines, etc.) and
environmental stimuli (physical parameters, xenobiotics, etc.). Oxidative stress appears to be …

Nascent transcripts in permeabilized HeLa cells were elongated by∼ 30-2,000 nucleotides
in Br-UTP or biotin-14-CTP, before incorporation sites were immunolabelled either pre-or …

Calorie restriction (CR), the only non-genetic intervention known to slow aging and extend
life span in organisms ranging from yeast to mice, has been linked to the down-regulation of …

In diabetes (type 1 and type 2), increased flux of free fatty acids and glucose is associated
with increased mitochondrial reactive oxygen species (ROS) production and, as a …

Transcription factors/activators are a group of proteins that bind to specific consensus
sequences (cis elements) in the promoter regions of downstream target/effector genes and …

In aged mice, the redox-regulated transcription factor nuclear factor-κB (NF-κB) becomes
constitutively active in many tissues, as well as in cells of the hematopoietic system. This …

Mitochondria are the major ATP producer of the mammalian cell. Moreover, mitochondria
are also the main intracellular source and target of reactive oxygen species (ROS) that are …