RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that
ensure the fidelity of translation, and dysregulation of the modification processes can cause …

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place
in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its …

Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-
bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2 …

Ribosomes are nanomachines essential for protein production in all living cells. Ribosome
synthesis increases in cancer cells to cope with a rise in protein synthesis and sustain …

Highlights•Ψ is overall the most abundant RNA modification.•Ψ is wide-spread in ncRNAs
and plays important roles for their functions.•Ψ can be induced upon stress …

Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides,
predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from …

Modifications of ribosomal RNA expand the nucleotide repertoire and thereby contribute to
ribosome heterogeneity and translational regulation of gene expression. One particular m5C …