Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current …
The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …
Penicillin binding proteins and β-lactamases of Mycobacterium tuberculosis: reexamination of the historical paradigm
Penicillin binding proteins (PBPs) have been extensively studied due to their importance to
the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used …
the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used …
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding
L Khodaparast, L Khodaparast, G Wu… - Nature …, 2023 - nature.com
There is an arms race between beta-lactam antibiotics development and co-evolving beta-
lactamases, which provide resistance by breaking down beta-lactam rings. We have …
lactamases, which provide resistance by breaking down beta-lactam rings. We have …
Flexible loops of New Delhi metallo-β-lactamase modulate its activity towards different substrates
JE Raczynska, B Imiolczyk, M Komorowska… - International journal of …, 2020 - Elsevier
Two accessory loop regions that are present in numerous variants of New Delhi metallo-β-
lactamases (NDM) are important for the enzymatic activity. The first one is a flexible loop L3 …
lactamases (NDM) are important for the enzymatic activity. The first one is a flexible loop L3 …
Deciphering the role of V88L substitution in NDM-24 metallo-β-lactamase
The New Delhi metallo-β-lactamase-1 (NDM-1) is a typical carbapenemase and plays a
crucial role in antibiotic-resistance bacterial infection. Phylogenetic analysis, performed on …
crucial role in antibiotic-resistance bacterial infection. Phylogenetic analysis, performed on …
Occurrence of blaNDM-1, blaNDM-5, blaNDM-7, and blaKPC-2 genes in clinical isolates of enterobacterales with high genetic variability, from colonization …
LR Martins, MIS Pimentel, ÉM de Oliveira… - Journal of Applied …, 2024 - academic.oup.com
Aims This study aimed to investigate the presence of beta-lactams resistance genes and the
clonal relationship of clinical isolates of Enterobacterales obtained from patients with and …
clonal relationship of clinical isolates of Enterobacterales obtained from patients with and …
The physiological role of Acinetobacter baumannii DacC is exerted through influencing cell shape, biofilm formation, the fitness of survival, and manifesting DD …
With the growing threat of drug-resistant Acinetobacter baumannii, there is an urgent need to
comprehensively understand the physiology of this nosocomial pathogen. As penicillin …
comprehensively understand the physiology of this nosocomial pathogen. As penicillin …
Role of non-active site residues in maintaining New Delhi metallo-β-lactamase-1 (NDM-1) function: an approach of site-directed mutagenesis and docking
New Delhi metallo-β-lactamase-1 (NDM-1) has been known to hydrolyze nearly all β-lactam
antibiotics, leading to a multidrug-resistant state. Hence, it is important to study its structure …
antibiotics, leading to a multidrug-resistant state. Hence, it is important to study its structure …
Involvement of the non-active site residues in the catalytic activity of NDM-4 metallo beta-lactamase
Abstract The rise of New Delhi metallo beta-lactamase (NDM) producing bacteria imposes a
significant threat to the treatment of bacterial infections due to their broad spectrum against …
significant threat to the treatment of bacterial infections due to their broad spectrum against …